Purpose: Carboplatin is used to treat many cancers, but occurrence of drug resistance and its high toxicity remain a clinical hurdle limiting its efficacy.We compared the efficacy and toxicity of DNA repair inhibitors olaparib or AsiDNA administered alone or in combination with carboplatin.Olaparib acts by inhibiting PARP-dependent repair pathways
The classification of high dimensional gene expression/ microarray data always plays an important role in various disease Skateboards diagnoses and drug discovery.To avoid the curse of high dimensionality, the selection of the most influential genes remains a challenging task for the researchers in the machine learning field.As the extraction of in
Introduction Background: Recently, a new instrument, the QUICK-BLAST Guilt And Shame Proneness Scale has been developed and showed promising psychometric properties.However, the Italian version of the Instrument has not still been validated.In addition, despite the growing number of studies on the topic, the knowledge regarding the role played by g
Careful definition and illustrative case studies are fundamental work in developing a Blue Economy.As blue research expands with the world increasingly understanding its importance, policy makers and research institutions worldwide concerned with ocean and coastal regions are demanding further and improved analysis of the Blue Economy.Particularly,